About Adequan i.m.

What is Adequan® i.m. (polysulfated glycosaminoglycan) ?
Is there a generic version available?

Mechanism of action & efficacy

What is the mechanism of action for Adequan i.m.?
What are the known pharmacokinetics of Adequan i.m. after a single injection?
What is the pharmacology of Adequan i.m.?

How to use Adequan i.m.

How is Adequan i.m. packaged?
What is the dosing regimen for a patient starting Adequan® i.m.?
Why is Adequan i.m. administered every 4 days?
What is the recommendation for Adequan i.m. for “prophylactic” or “maintenance” use? Is there a "loading" dose?
Is Adequan i.m. available in a multiple-use vial?
Is the Adequan i.m. Single-Dose vial or Adequan i.m Multi-Dose vial labeled for intravenous (IV) or subcutaneous (SQ) administration?
What are the differences in ingredients between Adequan i.m. Single-Dose vial and Adequan i.m. Multi-Dose vial?
Is there a recommendation as to where in the muscle Adequan i.m. should be administered?
Is Adequan i.m. approved for concurrent use with other products for joint disease?

Safety & approved uses

Are there any age or breed restrictions for Adequan i.m.?
Are there any contraindications?
Are there any side effects that may be observed?
Are there precautions for the use of Adequan i.m.?
Are there any warnings?
Is Adequan i.m. approved for use in pregnant or lactating mares or breeding stallions?
Is Adequan i.m. approved for use in horses with insulin dysregulation (ID), insulin resistance (IR), Equine Metabolic Syndrome (EMS), or Pituitary Pars Intermedia Dysfunction (PPID)?

Ordering & shipping

How do I order Adequan i.m.?
What should I do if I received product that was shipped in a method that differs from the recommended storage?
How do I return expired product?
What is the shelf life of Adequan i.m. Single-Dose vial and Multi-Dose vial?
Adequan i.m. was not shipped or received in optimal conditions for an extended or unknown period. Is it still safe and effective?

For more information

Who can I call with questions about Adequan i.m.?
Can horse owners purchase Adequan i.m. directly from American Regent Animal Health?
Need assistance or want more details?

Stay informed on Adequan i.m.

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  1. Kim DY, Taylor HW, Moore RM, Paulsen DB, Cho DY. Articular chondrocyte apoptosis in equine osteoarthritis. The Veterinary Journal. 2003;166:52-57.
  2. Burba DJ, Collier MA, DeBault LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articular cartilage in an osteochondral defect model. J Equine Vet Sci. 1993;13:696-703.
  3. McIlwraith CW, Frisbie DD, Kawcak CE, van Weeren PR. Joint Disease in the Horse. St. Louis, MO: Elsevier, 2016;33-48.
  4. Adequan® i.m. (polysulfated glycosaminoglycan), Package Insert. American Regent, Inc.